Protection for the Self-Employed in Japan: Needs and Measures

This article examines the protection needs of the self-employed and the developments in such protection in Japan. Arguments are put forward for further improving the protection for the self-employed beyond the existing protection framework. These efforts towards improving protection are expected to continue in the future. However, this is not to suggest that a specific stance has been adopted with regard to the content of such protection for those self-employed who are eligible. Such protection is still very much in the stage of preliminary consideration. While the development of such protection is still in the early stages, emergency steps taken in the COVID-19 pandemic have included income support measures to cover the loss of work for self-employed people whose tasks are similar to those of an employee. The self-employed who are eligible for such protection are those who seek protection. It may be argued that, regardless of the intentions of policy-makers, the policies that are pursued are a reflection of how the self-employed perceive their needs. © 2022 Kluwer Law International BV, The Netherlands

Mechanisms of instantaneous inactivation of SARS-CoV-2 by silicon nitride bioceramic.

The hydrolytic processes occurring at the surface of silicon nitride (Si3N4) bioceramic have been indicated as a powerful pathway to instantaneous inactivation of SARS-CoV-2 virus. However, the virus inactivation mechanisms promoted by Si3N4 remain yet to be elucidated. In this study, we provide evidence of the instantaneous damage incurred on the SARS-CoV-2 virus upon contact with Si3N4. We also emphasize the safety characteristics of Si3N4 for mammalian cells. Contact between the virions and micrometric Si3N4 particles immediately targeted a variety of viral molecules by inducing post-translational oxidative modifications of S-containing amino acids, nitration of the tyrosine residue in the spike receptor binding domain, and oxidation of RNA purines to form formamidopyrimidine. This structural damage in turn led to a reshuffling of the protein secondary structure. These clear fingerprints of viral structure modifications were linked to inhibition of viral functionality and infectivity. This study validates the notion that Si3N4 bioceramic is a safe and effective antiviral compound; and a primary antiviral candidate to replace the toxic and allergenic compounds presently used in contact with the human body and in long-term environmental sanitation.